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Clonal reconstruction from co-occurrence of vector integration sites accurately quantifies expanding clones in vivo
High transduction rates of viral vectors in gene therapies (GT) and experimental hematopoiesis ensure a high frequency of gene delivery, although multiple integration events can occur in the same cell. Therefore, tracing of integration sites (IS) leads to mis-quantification of the true clonal spectr...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240075/ https://www.ncbi.nlm.nih.gov/pubmed/35764632 http://dx.doi.org/10.1038/s41467-022-31292-6 |