Senescent cells limit p53 activity via multiple mechanisms to remain viable

Super-enhancers regulate genes with important functions in processes that are cell type-specific or define cell identity. Mouse embryonic fibroblasts establish 40 senescence-associated super-enhancers regardless of how they become senescent, with 50 activated genes located in the vicinity of these e...

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Detalles Bibliográficos
Autores principales: Sturmlechner, Ines, Sine, Chance C., Jeganathan, Karthik B., Zhang, Cheng, Fierro Velasco, Raul O., Baker, Darren J., Li, Hu, van Deursen, Jan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240076/
https://www.ncbi.nlm.nih.gov/pubmed/35764649
http://dx.doi.org/10.1038/s41467-022-31239-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240076/
https://www.ncbi.nlm.nih.gov/pubmed/35764649
http://dx.doi.org/10.1038/s41467-022-31239-x

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