Cargando…

Antisense Oligonucleotide-Based Therapy on miR-181a-5p Alleviates Cartilage Degradation of Temporomandibular Joint Osteoarthritis via Promoting SIRT1

Temporomandibular joint osteoarthritis (TMJOA) condylar cartilage degeneration and abnormal subchondral bone pathological remodeling induce pain and joint dysfunction, and cartilage degeneration is considered irreversible. Very few therapeutic approaches are administrated in practice. Nucleotides ha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qi, Hexu, Zhao, Zhenxing, Xu, Lin, Zhang, Yue, Li, Yifei, Xiao, Li, Li, Yu, Zhao, Zhihe, Fang, Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240346/ https://www.ncbi.nlm.nih.gov/pubmed/35784690 http://dx.doi.org/10.3389/fphar.2022.898334

Ejemplares similares

Knockout of miR-21-5p alleviates cartilage matrix degradation by targeting Gdf5 in temporomandibular joint osteoarthritis
por: Zhang, Aobo, et al.
Publicado: (2020)

Drug delivery systems for treatment of temporomandibular joint osteoarthritis
por: Huang, Xinqi, et al.
Publicado: (2022)

Hypoxia-inducible factor expression is related to apoptosis and cartilage degradation in temporomandibular joint osteoarthritis
por: Zhang, Jun, et al.
Publicado: (2022)

Mechanotransduction pathways in the regulation of cartilage chondrocyte homoeostasis
por: Zhao, Zhenxing, et al.
Publicado: (2020)

Progression of Cartilage Degradation, Bone Resorption and Pain in Rat Temporomandibular Joint Osteoarthritis Induced by Injection of Iodoacetate
por: Wang, Xue-Dong, et al.
Publicado: (2012)

Chondrocyte-derived exosomes promote cartilage calcification in temporomandibular joint osteoarthritis
por: Liu, Qian, et al.
Publicado: (2022)

A Tandem Oligonucleotide Approach for SNP-Selective RNA Degradation Using Modified Antisense Oligonucleotides
por: Magner, Dorota, et al.
Publicado: (2015)

Correction: A Tandem Oligonucleotide Approach for SNP-Selective RNA Degradation Using Modified Antisense Oligonucleotides
por: Magner, Dorota, et al.
Publicado: (2016)

Anabolic role of lysyl oxidase like-2 in cartilage of knee and temporomandibular joints with osteoarthritis
por: Alshenibr, Weam, et al.
Publicado: (2017)

BMSC-Derived Small Extracellular Vesicles Induce Cartilage Reconstruction of Temporomandibular Joint Osteoarthritis via Autotaxin–YAP Signaling Axis
por: Wang, Yingnan, et al.
Publicado: (2021)

Antisense oligonucleotides in neurological disorders
por: Wurster, Claudia D., et al.
Publicado: (2018)

Molecular Mechanisms of Antisense Oligonucleotides
por: Crooke, Stanley T.
Publicado: (2017)

Antisense oligonucleotides: A primer
por: Scoles, Daniel R., et al.
Publicado: (2019)

Antisense Oligonucleotides and RNA Interference
por: Kher, Gitanjali, et al.
Publicado: (2011)

Novel advances in strategies and applications of artificial articular cartilage
por: Chen, Yifei, et al.
Publicado: (2022)

Targeting Cartilage Degradation in Osteoarthritis
por: McClurg, Oliver, et al.
Publicado: (2021)

Short antisense oligonucleotides alleviate the pleiotropic toxicity of RNA harboring expanded CGG repeats
por: Derbis, Magdalena, et al.
Publicado: (2021)

Antisense Oligonucleotide-Based Therapy of Viral Infections
por: Tarn, Woan-Yuh, et al.
Publicado: (2021)

Estrogen-Related Receptor γ Induces Angiogenesis and Extracellular Matrix Degradation of Temporomandibular Joint Osteoarthritis in Rats
por: Zhao, Haoming, et al.
Publicado: (2019)

Targeting NLRP3 Inflammasome Alleviates Synovitis by Reducing Pyroptosis in Rats with Experimental Temporomandibular Joint Osteoarthritis
por: Xin, Yinzi, et al.
Publicado: (2022)

Antisense oligonucleotide and thyroid hormone conjugates for obesity treatment
por: Cao, Yang, et al.
Publicado: (2017)

Nonviral delivery systems for antisense oligonucleotide therapeutics
por: Huang, Si, et al.
Publicado: (2022)

Circadian Rhythm Protein Bmal1 Modulates Cartilage Gene Expression in Temporomandibular Joint Osteoarthritis via the MAPK/ERK Pathway
por: Chen, Guokun, et al.
Publicado: (2020)

Temporomandibular Joint Osteoarthritis: Pathogenic Mechanisms Involving the Cartilage and Subchondral Bone, and Potential Therapeutic Strategies for Joint Regeneration
por: Cardoneanu, Anca, et al.
Publicado: (2022)

Extracellular vesicles in osteoarthritis of peripheral joint and temporomandibular joint
por: Yang, Benyi, et al.
Publicado: (2023)

Opportunities and challenges for antisense oligonucleotide therapies
por: Kuijper, Elsa C., et al.
Publicado: (2020)

Silencing Antibiotic Resistance with Antisense Oligonucleotides
por: Jani, Saumya, et al.
Publicado: (2021)

Drug Discovery Perspectives of Antisense Oligonucleotides
por: Kim, Yeonjoon
Publicado: (2023)

In-silico study of antisense oligonucleotide antibiotics
por: Chen, Erica S., et al.
Publicado: (2023)

Metformin Mitigates Cartilage Degradation by Activating AMPK/SIRT1-Mediated Autophagy in a Mouse Osteoarthritis Model
por: Wang, Chenzhong, et al.
Publicado: (2020)

Antisense oligonucleotide therapy for KCNT1 encephalopathy
por: Burbano, Lisseth Estefania, et al.
Publicado: (2022)

Tongbi Huoluo Decoction alleviates cartilage degeneration in knee osteoarthritis by inhibiting degradation of extracellular matrix
por: Chen, Weijian, et al.
Publicado: (2023)

Defining the Factors That Contribute to On-Target Specificity of Antisense Oligonucleotides
por: Lima, Walt F., et al.
Publicado: (2014)

Isorhynchophylline alleviates cartilage degeneration in osteoarthritis by activating autophagy of chondrocytes
por: Jiang, Jieyun, et al.
Publicado: (2023)

Animal Models of Temporomandibular Joint Osteoarthritis: Classification and Selection
por: Zhao, Yuqing, et al.
Publicado: (2022)

Corrigendum: Circadian rhythm protein Bmal1 modulates cartilage gene expression in temporomandibular joint osteoarthritis via the MAPK/ERK pathway
por: Chen, Guokun, et al.
Publicado: (2022)

Reduction of Off-Target Effects of Gapmer Antisense Oligonucleotides by Oligonucleotide Extension
por: Yasuhara, Hidenori, et al.
Publicado: (2022)

Characterization of the Prion Protein Binding Properties of Antisense Oligonucleotides
por: Reidenbach, Andrew G., et al.
Publicado: (2019)

Molecular signaling in temporomandibular joint osteoarthritis
por: Lu, Ke, et al.
Publicado: (2021)

Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides
por: Anderson, Brooke A, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_qr7cmlfjf022fpj1mjgqpm6tfg