Cargando…

Optimized NGFR-derived hinges for rapid and efficient enrichment and detection of CAR T cells in vitro and in vivo

Chimeric antigen receptor (CAR) T cell therapy has demonstrated unprecedented success with high remission rates for heavily pretreated patients with hematological malignancies. The hinge connecting the extracellular antigen recognition unit to the transmembrane domain provides the length and flexibi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bister, A., Ibach, T., Haist, C., Gerhorst, G., Smorra, D., Soldierer, M., Roellecke, K., Wagenmann, M., Scheckenbach, K., Gattermann, N., Wiek, C., Hanenberg, H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240717/ https://www.ncbi.nlm.nih.gov/pubmed/35795096 http://dx.doi.org/10.1016/j.omto.2022.05.012

Ejemplares similares

A novel CD34-derived hinge for rapid and efficient detection and enrichment of CAR T cells
por: Bister, Arthur, et al.
Publicado: (2021)

Genetic Engineering and Enrichment of Human NK Cells for CAR-Enhanced Immunotherapy of Hematological Malignancies
por: Soldierer, Maren, et al.
Publicado: (2022)

Epigenetic Priming of Bladder Cancer Cells With Decitabine Increases Cytotoxicity of Human EGFR and CD44v6 CAR Engineered T-Cells
por: Grunewald, Camilla M., et al.
Publicado: (2021)

Extracellular NGFR Spacers Allow Efficient Tracking and Enrichment of Fully Functional CAR-T Cells Co-Expressing a Suicide Gene
por: Casucci, Monica, et al.
Publicado: (2018)

Synergistic Interaction of the Class IIa HDAC Inhibitor CHDI0039 with Bortezomib in Head and Neck Cancer Cells
por: Schrenk, Christian, et al.
Publicado: (2023)

Cytokine Patterns and Endotypes in Acute and Chronic Rhinosinusitis
por: Scheckenbach, Kathrin, et al.
Publicado: (2015)

Reducing Hinge Flexibility of CAR-T Cells Prolongs Survival In Vivo With Low Cytokines Release
por: Zhang, Ang, et al.
Publicado: (2021)

Reversal of pre-existing NGFR-driven tumor and immune therapy resistance
por: Boshuizen, Julia, et al.
Publicado: (2020)

The Effects of Chimeric Antigen Receptor (CAR) Hinge Domain Post-Translational Modifications on CAR-T Cell Activity
por: Hirobe, Sachiko, et al.
Publicado: (2022)

An intronic alteration of the fibroblast growth factor 10 gene causing ALSG-(aplasia of lacrimal and salivary glands) syndrome
por: Scheckenbach, Kathrin, et al.
Publicado: (2008)

Tröpfchenexposition bei Tracheotomie: Fallanalyse und Konsequenzen in Bezug auf COVID-19-Patienten
por: Plettenberg, C., et al.
Publicado: (2021)

Author Correction: Reversal of pre-existing NGFR-driven tumor and immune therapy resistance
por: Boshuizen, Julia, et al.
Publicado: (2023)

Genetic polymorphisms of nerve growth factor receptor (NGFR) and the risk of Alzheimer's disease
por: Cheng, Hui-Chi, et al.
Publicado: (2012)

Characterization of an Additional Splice Acceptor Site Introduced into CYP4B1 in Hominoidae during Evolution
por: Schmidt, Eva M., et al.
Publicado: (2015)

Escape from NK cell tumor surveillance by NGFR-induced lipid remodeling in melanoma
por: Lehmann, Julia, et al.
Publicado: (2023)

The Nerve Growth Factor Receptor (NGFR/p75(NTR)): A Major Player in Alzheimer’s Disease
por: Bruno, Francesco, et al.
Publicado: (2023)

Efficient Muscle Regeneration by Human PSC-Derived CD82(+) ERBB3(+) NGFR(+) Skeletal Myogenic Progenitors
por: Xie, Ning, et al.
Publicado: (2023)

ESM1 mediates NGFR-induced invasion and metastasis in murine oral squamous cell carcinoma
por: Chen, Chen, et al.
Publicado: (2016)

Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism.
por: García-Silva, Susana, et al.
Publicado: (2021)

Association of rs2072446 in the NGFR gene with the risk of Alzheimer's disease and amyloid‐β deposition in the brain
por: He, Chen‐Yang, et al.
Publicado: (2022)

Selection-free endogenous tagging of cell lines by bicistronic co-expression of the surface antigen NGFR
por: Seibert, Marcel, et al.
Publicado: (2022)

Muscle denervation promotes functional interactions between glial and mesenchymal cells through NGFR and NGF
por: Nicoletti, Chiara, et al.
Publicado: (2023)

Characterization of NGF, trkA(NGFR), and p75(NTR) in Retina of Mice Lacking Reelin Glycoprotein
por: Balzamino, Bijorn Omar, et al.
Publicado: (2014)

NGFR Gene and Single Nucleotide Polymorphisms, rs2072446 and rs11466162, Playing Roles in Psychiatric Disorders
por: Zhao, Longyou, et al.
Publicado: (2022)

Rapid Seismic Evaluation of Continuous Girder Bridges with Localized Plastic Hinges
por: Wei, Zhaolan, et al.
Publicado: (2022)

Understanding BRCA2 Function as a Tumor Suppressor Based on Domain-Specific Activities in DNA Damage Responses
por: Andreassen, Paul R., et al.
Publicado: (2021)

Static and dynamic analyses of free-hinged-hinged-hinged-free beam in non-homogeneous gravitational field: application to gravity gradiometry
por: Veryaskin, Alexey V., et al.
Publicado: (2022)

Flexible antibodies with nonprotein hinges
por: CAPON, Daniel J., et al.
Publicado: (2011)

Implication of TrkC‐miR2 in neurotrophin signalling pathway regulation through NGFR transcript targeting
por: Dokaneheifard, Sadat, et al.
Publicado: (2021)

Modification of Hinge/Transmembrane and Signal Transduction Domains Improves the Expression and Signaling Threshold of GXMR-CAR Specific to Cryptococcus spp.
por: dos Santos, Matheus Henrique, et al.
Publicado: (2022)

The checkpointkinase 2 (CHK2) 1100delC germ line mutation is not associated with the development of squamous cell carcinoma of the head and neck (SCCHN)
por: Scheckenbach, Kathrin, et al.
Publicado: (2010)

Posterior Dislocation of the Hinge-Post Extension in a Rotating Hinge Total Knee Prosthesis
por: Manzano, Givenchy, et al.
Publicado: (2013)

Experimental Verification of a Predicted Intronic MicroRNA in Human NGFR Gene with a Potential Pro-Apoptotic Function
por: Parsi, Sepideh, et al.
Publicado: (2012)

Expression of p75(NGFR), a Proliferative and Basal Cell Marker, in the Buccal Mucosa Epithelium during Re-epithelialization
por: Ishii, Akihiro, et al.
Publicado: (2014)

Extracellular domain, hinge, and transmembrane determinants affecting surface CD4 expression of a novel anti-HIV chimeric antigen receptor (CAR) construct
por: Zenere, Giorgio, et al.
Publicado: (2023)

Functional Ser205Leu polymorphism of the nerve growth factor receptor (NGFR) gene is associated with vagal autonomic dysregulation in humans
por: Chang, Chuan-Chia, et al.
Publicado: (2015)

Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer’s model of adult zebrafish brain
por: Bhattarai, Prabesh, et al.
Publicado: (2020)

A positive feedback loop formed by NGFR and FOXP3 contributes to the resistance of non-small cell lung cancer to icotinib
por: Huang, Jun, et al.
Publicado: (2020)

Resveratrol Induces Autophagy and Apoptosis in Non-Small-Cell Lung Cancer Cells by Activating the NGFR-AMPK-mTOR Pathway
por: Li, Jiaqiao, et al.
Publicado: (2022)

A hinge position distal to the adductor tubercle minimizes the risk of hinge fractures in lateral open wedge distal femoral osteotomy
por: Winkler, Philipp W., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_heju23uketfloonfc9d0phg7vj