Pharmacological inhibition of sphingolipid synthesis reduces ferroptosis by stimulating the HIF-1 pathway

Ferroptosis is crucial to the pathology of many neurological diseases. Here, we found pre-treatment with myriocin, an inhibitor of de novo synthesis of sphingolipid, significantly decreased the erastin- or glutamate-induced ferroptosis of HT22 cells without requiring the recovery of intracellular gl...

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Detalles Bibliográficos
Autores principales: Liu, Yang, He, Libo, Liu, Binghua, Ying, Yuling, Xu, Junling, Yu, Meng, Dang, Jinye, Liu, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240796/
https://www.ncbi.nlm.nih.gov/pubmed/35784791
http://dx.doi.org/10.1016/j.isci.2022.104533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240796/
https://www.ncbi.nlm.nih.gov/pubmed/35784791
http://dx.doi.org/10.1016/j.isci.2022.104533

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