Fluoxetine for reducing postoperative cognitive dysfunction in elderly patients after total knee replacement: study protocol for a single-centre, double-blind, randomised, parallel-group, superiority, placebo-controlled trial

INTRODUCTION: Postoperative cognitive dysfunction (POCD) is a common complication following major surgical procedures. The underlying pathophysiology is poorly understood, but the role of neuroinflammation is strongly implicated. Given the antineuroinflammatory and neuroprotective effects of fluoxet...

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Detalles Bibliográficos
Autores principales: Lin, Daoyi, Yu, Lulu, Chen, Jiaxin, Ye, Hong, Wu, Yushan, Yao, Yusheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Anaesthesia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240897/
https://www.ncbi.nlm.nih.gov/pubmed/35768113
http://dx.doi.org/10.1136/bmjopen-2021-057000

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240897/
https://www.ncbi.nlm.nih.gov/pubmed/35768113
http://dx.doi.org/10.1136/bmjopen-2021-057000

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