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Deciphering the functional mechanism of zinc ions of PARP1 binding with single strand breaks and double strand breaks
Poly(ADP-ribose)polymerase 1 (PARP1) is a key target for the treatment of cancer-related diseases, and plays an important role in biological processes such as DNA repair, regulating a variety of metabolic and signal transduction processes. Understanding the dynamic binding mechanisms between each do...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240923/ https://www.ncbi.nlm.nih.gov/pubmed/35865614 http://dx.doi.org/10.1039/d2ra02683j |