PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs

Effective systemic delivery of small interfering RNAs (siRNAs) to tissues other than liver remains a challenge. siRNAs are small (∼15 kDa) and therefore rapidly cleared by the kidneys, resulting in limited blood residence times and tissue exposure. Current strategies to improve the unfavorable pharm...

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Detalles Bibliográficos
Autores principales: Godinho, Bruno M.D.C., Knox, Emily G., Hildebrand, Samuel, Gilbert, James W., Echeverria, Dimas, Kennedy, Zachary, Haraszti, Reka A., Ferguson, Chantal M., Coles, Andrew H., Biscans, Annabelle, Caiazzi, Jillian, Alterman, Julia F., Hassler, Matthew R., Khvorova, Anastasia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240963/
https://www.ncbi.nlm.nih.gov/pubmed/35795486
http://dx.doi.org/10.1016/j.omtn.2022.06.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240963/
https://www.ncbi.nlm.nih.gov/pubmed/35795486
http://dx.doi.org/10.1016/j.omtn.2022.06.005

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