Cargando…

The down-regulation of XBP1, an unfolded protein response effector, promotes acute kidney injury to chronic kidney disease transition

BACKGROUND: The activation of the unfolded protein response (UPR) is closely linked to the pathogenesis of renal injuries. However, the role of XBP1, a crucial regulator of adaptive UPR, remains unclear during the transition from acute kidney injury (AKI) to chronic kidney disease (CKD). METHODS: We...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Jia-Huang, Wu, Chia-Hsien, Jheng, Jia-Rong, Chao, Chia-Ter, Huang, Jenq-Wen, Hung, Kuan-Yu, Liu, Shing-Hwa, Chiang, Chih-Kang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241279/ https://www.ncbi.nlm.nih.gov/pubmed/35765067 http://dx.doi.org/10.1186/s12929-022-00828-9

Ejemplares similares

Acute kidney injury as a risk factor for diagnostic discrepancy among geriatric patients: a pilot study
por: Chao, Chia-Ter, et al.
Publicado: (2016)

Thrombocytopenia on the first day of emergency department visit predicts higher risk of acute kidney injury among elderly patients
por: Chao, Chia-Ter, et al.
Publicado: (2017)

Therapeutic Approaches Targeting Proteostasis in Kidney Disease and Fibrosis
por: Chen, Jia-Huang, et al.
Publicado: (2021)

Repression of viral gene expression and replication by the unfolded protein response effector XBP1u
por: Hinte, Florian, et al.
Publicado: (2020)

Gustatory Function and the Uremic Toxin, Phosphate, Are Modulators of the Risk of Vascular Calcification among Patients with Chronic Kidney Disease: A Pilot Study
por: Chen, Shih-I, et al.
Publicado: (2020)

Contributors, risk associates, and complications of frailty in patients with chronic kidney disease: a scoping review
por: Wu, Patrick Yihong, et al.
Publicado: (2019)

N-Terminal Pro-Brain Natriuretic Peptide Predicts Long-Term Technique Failure in Patients Undergoing Peritoneal Dialysis
por: Chao, Chia-Ter, et al.
Publicado: (2018)

Therapeutic Ultrasound Halts Progression of Chronic Kidney Disease In Vivo via the Regulation of Markers Associated with Renal Epithelial–Mesenchymal Transition and Senescence
por: Lin, Chen-Yu, et al.
Publicado: (2022)

Comparative Study of Outcomes among Patients with Polycystic Kidney Disease on Hemodialysis and Peritoneal Dialysis
por: Yang, Ju-Yeh, et al.
Publicado: (2015)

Dipstick proteinuria level is significantly associated with pre-morbid and in-hospital functional status among hospitalized older adults: a preliminary study
por: Chao, Chia-Ter, et al.
Publicado: (2017)

Outcome Comparisons Between Patients on Peritoneal Dialysis With and Without Polycystic Kidney Disease: A Nationwide Matched Cohort Study
por: Yang, Ju-Yeh, et al.
Publicado: (2015)

Functional assessment of chronic illness therapy—the fatigue scale exhibits stronger associations with clinical parameters in chronic dialysis patients compared to other fatigue-assessing instruments
por: Chao, Chia-Ter, et al.
Publicado: (2016)

Cross-sectional study of the association between functional status and acute kidney injury in geriatric patients
por: Chao, Chia-Ter, et al.
Publicado: (2015)

The severity of initial acute kidney injury at admission of geriatric patients significantly correlates with subsequent in-hospital complications
por: Chao, Chia-Ter, et al.
Publicado: (2015)

Visceral fat area is associated with HbA1c but not dialysate-related glucose load in nondiabetic PD patients
por: Ho, Li-chun, et al.
Publicado: (2015)

Muscle relaxant use and the associated risk of incident frailty in patients with diabetic kidney disease: a longitudinal cohort study
por: Lee, Szu-Ying, et al.
Publicado: (2021)

pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response
por: Yoshida, Hiderou, et al.
Publicado: (2006)

Intracellular XBP1-IL-24 axis dismantles cytotoxic unfolded protein response in the liver
por: Wang, Jianye, et al.
Publicado: (2020)

Frailty increases the risk for developing urinary tract infection among 79,887 patients with diabetic mellitus and chronic kidney disease
por: Chao, Chia-Ter, et al.
Publicado: (2021)

Frailty modifies the association between opioid use and mortality in chronic kidney disease patients with diabetes: a population-based cohort study
por: Lee, Szu-Ying, et al.
Publicado: (2020)

Serum vitamin D levels are positively associated with varicella zoster immunity in chronic dialysis patients
por: Chao, Chia-Ter, et al.
Publicado: (2014)

Factors associated with poor outcomes of continuous renal replacement therapy
por: Kao, Chih-Chin, et al.
Publicado: (2017)

Frailty Predicts an Increased Risk of End-Stage Renal Disease with Risk Competition by Mortality among 165,461 Diabetic Kidney Disease Patients
por: Chao, Chia-Ter, et al.
Publicado: (2019)

Gender-Related Differences in Chronic Kidney Disease-Associated Vascular Calcification Risk and Potential Risk Mediators: A Scoping Review
por: Wu, Patrick Yihong, et al.
Publicado: (2021)

Targeting the unfolded protein response, XBP1, and the NLRP3 inflammasome in fibrosis and cancer
por: Overley-Adamson, Beth, et al.
Publicado: (2014)

C/EBP homologous protein (CHOP) deficiency ameliorates renal fibrosis in unilateral ureteral obstructive kidney disease
por: Liu, Shing-Hwa, et al.
Publicado: (2016)

Prevention of acute kidney injury by low intensity pulsed ultrasound via anti-inflammation and anti-apoptosis
por: Chiang, Chih-Kang, et al.
Publicado: (2020)

XBP1-KLF9 Axis Acts as a Molecular Rheostat to Control the Transition from Adaptive to Cytotoxic Unfolded Protein Response
por: Fink, Emily E., et al.
Publicado: (2018)

Cumulative Cardiovascular Polypharmacy Is Associated With the Risk of Acute Kidney Injury in Elderly Patients
por: Chao, Chia-Ter, et al.
Publicado: (2015)

Identification of Doxorubicin as an Inhibitor of the IRE1α-XBP1 Axis of the Unfolded Protein Response
por: Jiang, Dadi, et al.
Publicado: (2016)

A nationwide survey of healthcare personnel’s attitude, knowledge, and interest toward renal supportive care in Taiwan
por: Tsai, Hung-Bin, et al.
Publicado: (2017)

GCN5 inhibits XBP-1S-mediated transcription by antagonizing PCAF action
por: Lew, Qiao Jing, et al.
Publicado: (2014)

Frailty predicts a higher risk of incident urolithiasis in 525 368 patients with diabetes mellitus: a population-based study
por: Chao, Chia-Ter, et al.
Publicado: (2020)

Paramyxovirus replication induces the hexosamine biosynthetic pathway and mesenchymal transition via the IRE1α-XBP1s arm of the unfolded protein response
por: Qiao, Dianhua, et al.
Publicado: (2021)

Inhibition of IRE1α-mediated XBP1 mRNA cleavage by XBP1 reveals a novel regulatory process during the unfolded protein response
por: Chalmers, Fiona, et al.
Publicado: (2017)

Kidney function decline after a non-dialysis-requiring acute kidney injury is associated with higher long-term mortality in critically ill survivors
por: Lai, Chun-Fu, et al.
Publicado: (2012)

The context-dependent role of transforming growth factor-β/miR-378a-3p/connective tissue growth factor in vascular calcification: a translational study
por: Tsai, You-Tien, et al.
Publicado: (2023)

Proteinuria as a Therapeutic Target in Advanced Chronic Kidney Disease: a Retrospective Multicenter Cohort Study
por: Chen, Chang-Hsu, et al.
Publicado: (2016)

XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum
por: Sriburi, Rungtawan, et al.
Publicado: (2004)

Unfolded protein response mediator, the IRE1α-XBP1 pathway is involved in osteoblast differentiation
por: Tohmonda, Takahide, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_ggtprehr9mlp3f5pijgf7iubtf