KCNQ1-deficient and KCNQ1-mutant human embryonic stem cell-derived cardiomyocytes for modeling QT prolongation

BACKGROUND: The slowly activated delayed rectifier potassium current (I(Ks)) mediated by the KCNQ1 gene is one of the main currents involved in repolarization. KCNQ1 mutation can result in long-QT syndrome type 1 (LQT1). I(Ks) does not participate in repolarization in mice; thus, no good model is cu...

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Detalles Bibliográficos
Autores principales: Song, Yuanxiu, Guo, Tianwei, Jiang, Youxu, Zhu, Min, Wang, Hongyue, Lu, Wenjing, Jiang, Mengqi, Qi, Man, Lan, Feng, Cui, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241307/
https://www.ncbi.nlm.nih.gov/pubmed/35765105
http://dx.doi.org/10.1186/s13287-022-02964-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241307/
https://www.ncbi.nlm.nih.gov/pubmed/35765105
http://dx.doi.org/10.1186/s13287-022-02964-3

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