The discovery of penta-peptides inhibiting the activity of the formylglycine-generating enzyme and their potential antibacterial effects against Mycobacterium tuberculosis

The formylglycine-generating enzyme is a key regulator that converts sulfatase into an active form. Despite its key role in many diseases, enzyme activity inhibitors have not yet been reported. In this study, we investigated penta-peptide ligands for FGE activity inhibition and discovered two hit pe...

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Detalles Bibliográficos
Autores principales: Asiimwe, Nicholas, Al Mazid, Mohammad Faysal, Jeong, Yong Taek, Lee, Juyong, Lee, Jun-Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241360/
https://www.ncbi.nlm.nih.gov/pubmed/35873338
http://dx.doi.org/10.1039/d2ra03379h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241360/
https://www.ncbi.nlm.nih.gov/pubmed/35873338
http://dx.doi.org/10.1039/d2ra03379h

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