The discovery of penta-peptides inhibiting the activity of the formylglycine-generating enzyme and their potential antibacterial effects against Mycobacterium tuberculosis

The formylglycine-generating enzyme is a key regulator that converts sulfatase into an active form. Despite its key role in many diseases, enzyme activity inhibitors have not yet been reported. In this study, we investigated penta-peptide ligands for FGE activity inhibition and discovered two hit pe...

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Detalles Bibliográficos
Autores principales: Asiimwe, Nicholas, Al Mazid, Mohammad Faysal, Jeong, Yong Taek, Lee, Juyong, Lee, Jun-Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241360/
https://www.ncbi.nlm.nih.gov/pubmed/35873338
http://dx.doi.org/10.1039/d2ra03379h
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author Asiimwe, Nicholas
Al Mazid, Mohammad Faysal
Jeong, Yong Taek
Lee, Juyong
Lee, Jun-Seok
author_facet Asiimwe, Nicholas
Al Mazid, Mohammad Faysal
Jeong, Yong Taek
Lee, Juyong
Lee, Jun-Seok
author_sort Asiimwe, Nicholas
collection PubMed
description The formylglycine-generating enzyme is a key regulator that converts sulfatase into an active form. Despite its key role in many diseases, enzyme activity inhibitors have not yet been reported. In this study, we investigated penta-peptide ligands for FGE activity inhibition and discovered two hit peptides. In addition, the lead peptides also showed potential antibacterial effects in a Mycobacterium tuberculosis model.
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spelling pubmed-92413602022-07-22 The discovery of penta-peptides inhibiting the activity of the formylglycine-generating enzyme and their potential antibacterial effects against Mycobacterium tuberculosis Asiimwe, Nicholas Al Mazid, Mohammad Faysal Jeong, Yong Taek Lee, Juyong Lee, Jun-Seok RSC Adv Chemistry The formylglycine-generating enzyme is a key regulator that converts sulfatase into an active form. Despite its key role in many diseases, enzyme activity inhibitors have not yet been reported. In this study, we investigated penta-peptide ligands for FGE activity inhibition and discovered two hit peptides. In addition, the lead peptides also showed potential antibacterial effects in a Mycobacterium tuberculosis model. The Royal Society of Chemistry 2022-06-29 /pmc/articles/PMC9241360/ /pubmed/35873338 http://dx.doi.org/10.1039/d2ra03379h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Asiimwe, Nicholas
Al Mazid, Mohammad Faysal
Jeong, Yong Taek
Lee, Juyong
Lee, Jun-Seok
The discovery of penta-peptides inhibiting the activity of the formylglycine-generating enzyme and their potential antibacterial effects against Mycobacterium tuberculosis
title The discovery of penta-peptides inhibiting the activity of the formylglycine-generating enzyme and their potential antibacterial effects against Mycobacterium tuberculosis
title_full The discovery of penta-peptides inhibiting the activity of the formylglycine-generating enzyme and their potential antibacterial effects against Mycobacterium tuberculosis
title_fullStr The discovery of penta-peptides inhibiting the activity of the formylglycine-generating enzyme and their potential antibacterial effects against Mycobacterium tuberculosis
title_full_unstemmed The discovery of penta-peptides inhibiting the activity of the formylglycine-generating enzyme and their potential antibacterial effects against Mycobacterium tuberculosis
title_short The discovery of penta-peptides inhibiting the activity of the formylglycine-generating enzyme and their potential antibacterial effects against Mycobacterium tuberculosis
title_sort discovery of penta-peptides inhibiting the activity of the formylglycine-generating enzyme and their potential antibacterial effects against mycobacterium tuberculosis
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241360/
https://www.ncbi.nlm.nih.gov/pubmed/35873338
http://dx.doi.org/10.1039/d2ra03379h
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