Precise immunological evaluation rationalizes the design of a self-adjuvanting vaccine composed of glycan antigen, TLR1/2 ligand, and T-helper cell epitope

Sialyl-Tn (STn), overexpressed on various tumors, has been investigated for its application in anti-cancer vaccine therapy. However, Theratope, an STn-based vaccine, failed in the phase III clinical trial due to poor immunogenicity and epitope suppression by the foreign carrier protein. We therefore...

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Detalles Bibliográficos
Autores principales: Chang, Tsung-Che, Manabe, Yoshiyuki, Ito, Keita, Yamamoto, Ryuku, Kabayama, Kazuya, Ohshima, Shino, Kametani, Yoshie, Fujimoto, Yukari, Lin, Chun-Cheng, Fukase, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241363/
https://www.ncbi.nlm.nih.gov/pubmed/35873332
http://dx.doi.org/10.1039/d2ra03286d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241363/
https://www.ncbi.nlm.nih.gov/pubmed/35873332
http://dx.doi.org/10.1039/d2ra03286d

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