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Precise immunological evaluation rationalizes the design of a self-adjuvanting vaccine composed of glycan antigen, TLR1/2 ligand, and T-helper cell epitope
Sialyl-Tn (STn), overexpressed on various tumors, has been investigated for its application in anti-cancer vaccine therapy. However, Theratope, an STn-based vaccine, failed in the phase III clinical trial due to poor immunogenicity and epitope suppression by the foreign carrier protein. We therefore...
Autores principales: | Chang, Tsung-Che, Manabe, Yoshiyuki, Ito, Keita, Yamamoto, Ryuku, Kabayama, Kazuya, Ohshima, Shino, Kametani, Yoshie, Fujimoto, Yukari, Lin, Chun-Cheng, Fukase, Koichi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241363/ https://www.ncbi.nlm.nih.gov/pubmed/35873332 http://dx.doi.org/10.1039/d2ra03286d |
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