POLQ suppresses genome instability and alterations in DNA repeat tract lengths

DNA polymerase theta (POLQ) is a principal component of the alternative non-homologous end-joining (ANHEJ) DNA repair pathway that ligates DNA double-strand breaks. Utilizing independent models of POLQ insufficiency during telomere-driven crisis, we found that POLQ(–)(/–) cells are resistant to cris...

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Detalles Bibliográficos
Autores principales: Liddiard, Kate, Aston-Evans, Alys N, Cleal, Kez, Hendrickson, Eric A, Baird, Duncan M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Cancer Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241439/
https://www.ncbi.nlm.nih.gov/pubmed/35774233
http://dx.doi.org/10.1093/narcan/zcac020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241439/
https://www.ncbi.nlm.nih.gov/pubmed/35774233
http://dx.doi.org/10.1093/narcan/zcac020

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