EGR2 Deletion Suppresses Anti-DsDNA Autoantibody and IL-17 Production in Autoimmune-Prone B6/lpr Mice: A Differential Immune Regulatory Role of EGR2 in B6/lpr Versus Normal B6 Mice

Previous studies have reported that deletion of the transcription factor, early growth response protein 2 (EGR2), in normal C57BL/6 (B6) resulted in the development of lupus-like autoimmune disease. However, increased EGR2 expression has been noted in human and murine lupus, which challenges the not...

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Detalles Bibliográficos
Autores principales: Dai, Rujuan, Wang, Zhuang, Heid, Bettina, Eden, Kristin, Reilly, Christopher M., Ahmed, S. Ansar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241489/
https://www.ncbi.nlm.nih.gov/pubmed/35784356
http://dx.doi.org/10.3389/fimmu.2022.917866

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241489/
https://www.ncbi.nlm.nih.gov/pubmed/35784356
http://dx.doi.org/10.3389/fimmu.2022.917866

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