Cargando…

Mutation L319Q in the PB1 Polymerase Subunit Improves Attenuation of a Candidate Live-Attenuated Influenza A Virus Vaccine

Influenza A viruses (IAV) remain emerging threats to human public health. Live-attenuated influenza vaccines (LAIV) are one of the most effective prophylactic options to prevent disease caused by influenza infections. However, licensed LAIV remain restricted for use in 2- to 49-year-old healthy and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nogales, Aitor, Steel, John, Liu, Wen-Chun, Lowen, Anice C., Rodriguez, Laura, Chiem, Kevin, Cox, Andrew, García-Sastre, Adolfo, Albrecht, Randy A., Dewhurst, Stephen, Martínez-Sobrido, Luis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241597/ https://www.ncbi.nlm.nih.gov/pubmed/35583364 http://dx.doi.org/10.1128/spectrum.00078-22

Ejemplares similares

Increasing the Safety Profile of the Master Donor Live Attenuated Influenza Vaccine
por: Hilimire, Thomas A., et al.
Publicado: (2020)

Vaccinia Virus Attenuation by Codon Deoptimization of the A24R Gene for Vaccine Development
por: Lorenzo, María M., et al.
Publicado: (2022)

A Mutated PB1 Residue 319 Synergizes with the PB2 N265S Mutation of the Live Attenuated Influenza Vaccine to Convey Temperature Sensitivity
por: Cox, Andrew, et al.
Publicado: (2020)

Temperature Sensitive Mutations in Influenza A Viral Ribonucleoprotein Complex Responsible for the Attenuation of the Live Attenuated Influenza Vaccine
por: Martínez-Sobrido, Luis, et al.
Publicado: (2018)

A New Master Donor Virus for the Development of Live-Attenuated Influenza B Virus Vaccines
por: White, Chantelle L., et al.
Publicado: (2021)

Novel Approaches for The Development of Live Attenuated Influenza Vaccines
por: Blanco-Lobo, Pilar, et al.
Publicado: (2019)

Live attenuated influenza A virus vaccines with modified NS1 proteins for veterinary use
por: Nogales, Aitor, et al.
Publicado: (2022)

Comparative Study of the Temperature Sensitive, Cold Adapted and Attenuated Mutations Present in the Master Donor Viruses of the Two Commercial Human Live Attenuated Influenza Vaccines
por: Rodriguez, Laura, et al.
Publicado: (2019)

Host- and Strain-Specific Regulation of Influenza Virus Polymerase Activity by Interacting Cellular Proteins
por: Bortz, Eric, et al.
Publicado: (2011)

Mutation E48K in PB1 Polymerase Subunit Improves Stability of a Candidate Live Attenuated Influenza B Virus Vaccine
por: Mo, Jongsuk, et al.
Publicado: (2021)

Amino Acid Residues Involved in Inhibition of Host Gene Expression by Influenza A/Brevig Mission/1/1918 PA-X
por: Chiem, Kevin, et al.
Publicado: (2021)

Development of a novel equine influenza virus live-attenuated vaccine
por: Rodriguez, Laura, et al.
Publicado: (2018)

Transmission of Influenza Virus in a Mammalian Host Is Increased by PB2 Amino Acids 627K or 627E/701N
por: Steel, John, et al.
Publicado: (2009)

Transmission of Influenza Virus via Aerosols and Fomites in the Guinea Pig Model
por: Mubareka, Samira, et al.
Publicado: (2009)

Functional Characterization and Direct Comparison of Influenza A, B, C, and D NS1 Proteins in vitro and in vivo
por: Nogales, Aitor, et al.
Publicado: (2019)

A Bivalent Live-Attenuated Vaccine for the Prevention of Equine Influenza Virus
por: Blanco-Lobo, Pilar, et al.
Publicado: (2019)

Mutations Designed by Ensemble Defect to Misfold Conserved RNA Structures of Influenza A Segments 7 and 8 Affect Splicing and Attenuate Viral Replication in Cell Culture
por: Jiang, Tian, et al.
Publicado: (2016)

Influenza Virus Vaccine Based on the Conserved Hemagglutinin Stalk Domain
por: Steel, John, et al.
Publicado: (2010)

A Live Attenuated Influenza Vaccine Elicits Enhanced Heterologous Protection When the Internal Genes of the Vaccine Are Matched to Those of the Challenge Virus
por: Smith, Andrew, et al.
Publicado: (2020)

Replication-Competent ΔNS1 Influenza A Viruses Expressing Reporter Genes
por: Nogales, Aitor, et al.
Publicado: (2021)

An Alanine-to-Valine Substitution in the Residue 175 of Zika Virus NS2A Protein Affects Viral RNA Synthesis and Attenuates the Virus In Vivo
por: Márquez-Jurado, Silvia, et al.
Publicado: (2018)

993. Combining Key Residues of the Russian and US Live-Attenuated Influenza Viruses for a More Attenuated Virus
por: Smith, Andrew, et al.
Publicado: (2018)

Reverse Genetics Approaches for the Development of Influenza Vaccines
por: Nogales, Aitor, et al.
Publicado: (2016)

Transmission in the Guinea Pig Model
por: Lowen, Anice C., et al.
Publicado: (2014)

Mutations in the NS1 C-terminal tail do not enhance replication or virulence of the 2009 pandemic H1N1 influenza A virus
por: Hale, Benjamin G., et al.
Publicado: (2010)

Influenza Virus Transmission Is Dependent on Relative Humidity and Temperature
por: Lowen, Anice C, et al.
Publicado: (2007)

A Lassa Fever Live-Attenuated Vaccine Based on Codon Deoptimization of the Viral Glycoprotein Gene
por: Cai, Yingyun, et al.
Publicado: (2020)

A Lassa Virus Live-Attenuated Vaccine Candidate Based on Rearrangement of the Intergenic Region
por: Cai, Yingyun, et al.
Publicado: (2020)

H5N8 and H7N9 packaging signals constrain HA reassortment with a seasonal H3N2 influenza A virus
por: White, Maria C., et al.
Publicado: (2019)

Structural basis for therapeutic inhibition of influenza A polymerase PB2 subunit
por: Ma, Xiaolei, et al.
Publicado: (2017)

Influenza Virus Reassortment Occurs with High Frequency in the Absence of Segment Mismatch
por: Marshall, Nicolle, et al.
Publicado: (2013)

319 Bronchial Hyperresponsiveness in Obese Adolescents
por: Ramírez, Gabriela, et al.
Publicado: (2012)

Health Tract, No. 319: Poverty and Longevity
Publicado: (1868)

Bi-Reporter Vaccinia Virus for Tracking Viral Infections In Vitro and In Vivo
por: Chiem, Kevin, et al.
Publicado: (2021)

Identification of In Vitro Inhibitors of Monkeypox Replication
por: Chiem, Kevin, et al.
Publicado: (2023)

Polymerase Mechanism-Based Method of Viral Attenuation
por: Lee, Cheri A., et al.
Publicado: (2015)

Sequential Immunization With Live-Attenuated Chimeric Hemagglutinin-Based Vaccines Confers Heterosubtypic Immunity Against Influenza A Viruses in a Preclinical Ferret Model
por: Liu, Wen-Chun, et al.
Publicado: (2019)

Influenza Virus Reassortment Is Enhanced by Semi-infectious Particles but Can Be Suppressed by Defective Interfering Particles
por: Fonville, Judith M., et al.
Publicado: (2015)

The PB2 Subunit of the Influenza A Virus RNA Polymerase Is Imported into the Mitochondrial Matrix
por: Long, Joshua C. D., et al.
Publicado: (2016)

Amino acid sites related to the PB2 subunits of IDV affect polymerase activity
por: Wang, Yutian, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_456h3m409e239o51immmvt2qus