Selective Metal Chelation by a Thiosemicarbazone Derivative Interferes with Mitochondrial Respiration and Ribosome Biogenesis in Candida albicans

Metal chelation is generally considered as a promising antifungal approach but its specific mechanisms are unclear. Here, we identify 13 thiosemicarbazone derivatives that exert broad-spectrum antifungal activity with potency comparable or superior to that of fluconazole in vitro by screening a smal...

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Detalles Bibliográficos
Autores principales: Duan, Ximeng, Xie, Zhiyu, Ma, Liying, Jin, Xueyang, Zhang, Ming, Xu, Yuliang, Liu, Yue, Lou, Hongxiang, Chang, Wenqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241695/
https://www.ncbi.nlm.nih.gov/pubmed/35412374
http://dx.doi.org/10.1128/spectrum.01951-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241695/
https://www.ncbi.nlm.nih.gov/pubmed/35412374
http://dx.doi.org/10.1128/spectrum.01951-21

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