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Development of an Effective Nontoxigenic Clostridioides difficile–Based Oral Vaccine against C. difficile Infection

The symptoms of Clostridioides difficile infection (CDI) are largely attributed to two C. difficile toxins, TcdA and TcdB. Significant efforts have been devoted to developing vaccines targeting both toxins through parenteral immunization routes. Recently, we generated a novel chimeric protein (desig...

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Detalles Bibliográficos
Autores principales: Wang, Shaohui, Zhu, Duolong, Sun, Xingmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241731/
https://www.ncbi.nlm.nih.gov/pubmed/35583336
http://dx.doi.org/10.1128/spectrum.00263-22