Crizotinib Shows Antibacterial Activity against Gram-Positive Bacteria by Reducing ATP Production and Targeting the CTP Synthase PyrG

Infections caused by drug-resistant bacteria are a serious threat to public health worldwide, and the discovery of novel antibacterial compounds is urgently needed. Here, we screened an FDA-approved small-molecule library and found that crizotinib possesses good antimicrobial efficacy against Gram-p...

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Detalles Bibliográficos
Autores principales: Zheng, Yun-Dan, Zhong, Tairan, Wu, Haiming, Li, Nan, Fang, Zuye, Cao, Linlin, Yin, Xing-Feng, He, Qing-Yu, Ge, Ruiguang, Sun, Xuesong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241945/
https://www.ncbi.nlm.nih.gov/pubmed/35674439
http://dx.doi.org/10.1128/spectrum.00884-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241945/
https://www.ncbi.nlm.nih.gov/pubmed/35674439
http://dx.doi.org/10.1128/spectrum.00884-22

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