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Gramicidin A accumulates in mitochondria, reduces ATP levels, induces mitophagy, and inhibits cancer cell growth

Gramicidin A (1) is a linear 15-mer peptidic natural product. Because of its sequence of alternating d- and l-chirality, 1 folds into a β(6.3)-helix in a lipid bilayer and forms a head-to-head dimer to function as a transmembrane channel for monovalent cations (H(+), Na(+), and K(+)). The potent ant...

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Detalles Bibliográficos
Autores principales: Xue, Yun-Wei, Itoh, Hiroaki, Dan, Shingo, Inoue, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241976/
https://www.ncbi.nlm.nih.gov/pubmed/35872830
http://dx.doi.org/10.1039/d2sc02024f