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Gramicidin A accumulates in mitochondria, reduces ATP levels, induces mitophagy, and inhibits cancer cell growth
Gramicidin A (1) is a linear 15-mer peptidic natural product. Because of its sequence of alternating d- and l-chirality, 1 folds into a β(6.3)-helix in a lipid bilayer and forms a head-to-head dimer to function as a transmembrane channel for monovalent cations (H(+), Na(+), and K(+)). The potent ant...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241976/ https://www.ncbi.nlm.nih.gov/pubmed/35872830 http://dx.doi.org/10.1039/d2sc02024f |