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Modeling of SGLT1 in Reconstituted Systems Reveals Apparent Ion-Dependencies of Glucose Uptake and Strengthens the Notion of Water-Permeable Apo States

The reconstitution of secondary active transporters into liposomes shed light on their molecular transport mechanism. The latter are either symporters, antiporters or exchangers, which use the energy contained in the electrochemical gradient of ions to fuel concentrative uptake of their cognate subs...

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Detalles Bibliográficos
Autores principales: Barta, Thomas, Sandtner, Walter, Wachlmayr, Johann, Hannesschlaeger, Christof, Ebert, Andrea, Speletz, Armin, Horner, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242095/
https://www.ncbi.nlm.nih.gov/pubmed/35784872
http://dx.doi.org/10.3389/fphys.2022.874472