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Acidification of endothelial Weibel-Palade bodies is mediated by the vacuolar-type H(+)-ATPase

Weibel-Palade bodies (WPB) are unique secretory granules of endothelial cells that store the procoagulant von-Willebrand factor (VWF) in a highly compacted form. Upon exocytosis the densely packed VWF unfurls into long strands that expose binding sites for circulating platelets and thereby initiate...

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Detalles Bibliográficos
Autores principales:	Terglane, Julian, Menche, Dirk, Gerke, Volker
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242466/ https://www.ncbi.nlm.nih.gov/pubmed/35767558 http://dx.doi.org/10.1371/journal.pone.0270299

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