Mitochondrial dysfunction is associated with lipid metabolism disorder and upregulation of angiotensin-converting enzyme 2

Thymidine kinase 2 (TK2) deficiency in humans leads to a myopathic form of mitochondrial DNA (mtDNA) deficiency. Here we present a skeletal and cardiac muscle specific TK2 knockout mouse (mTk2 KO). The mice showed dilated hearts and markedly reduced adipose tissue during week 12 to 16. A severe decr...

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Detalles Bibliográficos
Autores principales: Zhao, Qian, Zhou, Xiaoshan, Kuiper, Raoul, Curbo, Sophie, Karlsson, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242481/
https://www.ncbi.nlm.nih.gov/pubmed/35767531
http://dx.doi.org/10.1371/journal.pone.0270418

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242481/
https://www.ncbi.nlm.nih.gov/pubmed/35767531
http://dx.doi.org/10.1371/journal.pone.0270418

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