Importance of Rare DPYD Genetic Polymorphisms for 5-Fluorouracil Therapy in the Japanese Population

Dihydropyrimidine dehydrogenase (DPD), encoded by the DPYD gene, is the rate-limiting enzyme in 5-fluorouracil (5-FU) degradation. In Caucasians, four DPYD risk variants are recognized to be responsible for interindividual variations in the development of 5-FU toxicity. However, these risk variants...

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Detalles Bibliográficos
Autores principales: Hishinuma, Eiji, Narita, Yoko, Obuchi, Kai, Ueda, Akiko, Saito, Sakae, Tadaka, Shu, Kinoshita, Kengo, Maekawa, Masamitsu, Mano, Nariyasu, Hirasawa, Noriyasu, Hiratsuka, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242541/
https://www.ncbi.nlm.nih.gov/pubmed/35784703
http://dx.doi.org/10.3389/fphar.2022.930470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242541/
https://www.ncbi.nlm.nih.gov/pubmed/35784703
http://dx.doi.org/10.3389/fphar.2022.930470

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