Tonic inhibition of the chloride/proton antiporter ClC-7 by PI(3,5)P2 is crucial for lysosomal pH maintenance

The acidic luminal pH of lysosomes, maintained within a narrow range, is essential for proper degrative function of the organelle and is generated by the action of a V-type H(+) ATPase, but other pathways for ion movement are required to dissipate the voltage generated by this process. ClC-7, a Cl(-...

Descripción completa

Detalles Bibliográficos
Autores principales: Leray, Xavier, Hilton, Jacob K, Nwangwu, Kamsi, Becerril, Alissa, Mikusevic, Vedrana, Fitzgerald, Gabriel, Amin, Anowarul, Weston, Mary R, Mindell, Joseph A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242644/
https://www.ncbi.nlm.nih.gov/pubmed/35670560
http://dx.doi.org/10.7554/eLife.74136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242644/
https://www.ncbi.nlm.nih.gov/pubmed/35670560
http://dx.doi.org/10.7554/eLife.74136

Ejemplares similares