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Tonic inhibition of the chloride/proton antiporter ClC-7 by PI(3,5)P2 is crucial for lysosomal pH maintenance
The acidic luminal pH of lysosomes, maintained within a narrow range, is essential for proper degrative function of the organelle and is generated by the action of a V-type H(+) ATPase, but other pathways for ion movement are required to dissipate the voltage generated by this process. ClC-7, a Cl(-...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242644/ https://www.ncbi.nlm.nih.gov/pubmed/35670560 http://dx.doi.org/10.7554/eLife.74136 |