Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function

Mutations in the lever arm of β-cardiac myosin are a frequent cause of hypertrophic cardiomyopathy, a disease characterized by hypercontractility and eventual hypertrophy of the left ventricle. Here, we studied five such mutations: three in the pliant region of the lever arm (D778V, L781P, and S782N...

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Detalles Bibliográficos
Autores principales: Morck, Makenna M, Bhowmik, Debanjan, Pathak, Divya, Dawood, Aminah, Spudich, James, Ruppel, Kathleen M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242648/
https://www.ncbi.nlm.nih.gov/pubmed/35767336
http://dx.doi.org/10.7554/eLife.76805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242648/
https://www.ncbi.nlm.nih.gov/pubmed/35767336
http://dx.doi.org/10.7554/eLife.76805

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