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The Role of Connexin in Ophthalmic Neovascularization and the Interaction between Connexin and Proangiogenic Factors

The formation of new blood vessels is an important physiological process that occurs during development. When the body is injured, new blood vessel formation helps the body recuperate by supplying more oxygen and nutrients. However, this mechanism can have a negative effect. In ophthalmologic diseas...

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Detalles Bibliográficos
Autores principales: Xu, Chuyang, Zhang, Hong, Zhong, Wei, Zhou, Hongyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242797/
https://www.ncbi.nlm.nih.gov/pubmed/35783340
http://dx.doi.org/10.1155/2022/8105229
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author Xu, Chuyang
Zhang, Hong
Zhong, Wei
Zhou, Hongyan
author_facet Xu, Chuyang
Zhang, Hong
Zhong, Wei
Zhou, Hongyan
author_sort Xu, Chuyang
collection PubMed
description The formation of new blood vessels is an important physiological process that occurs during development. When the body is injured, new blood vessel formation helps the body recuperate by supplying more oxygen and nutrients. However, this mechanism can have a negative effect. In ophthalmologic diseases, such as corneal new blood vessels, neonatal vascular glaucoma, and diabetes retinopathy, the formation of new blood vessels has become a critical component in patient survival. Connexin is a protein that regulates the cellular and molecular material carried by cells. It has been demonstrated that it is widely expressed in vascular endothelial cells, where it forms a slit connection between adjacent cells to promote cell-cell communication via hemichannels, as well as substance exchange into intracellular environments. Numerous studies have demonstrated that connexin in vascular endothelial cells plays an important role in angiogenesis and vascular leakage. The purpose of this study was to investigate the effect between the angiogenesis-associated factor and the connexin. It also reveals the effect of connexin on ophthalmic neovascularization.
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spelling pubmed-92427972022-06-30 The Role of Connexin in Ophthalmic Neovascularization and the Interaction between Connexin and Proangiogenic Factors Xu, Chuyang Zhang, Hong Zhong, Wei Zhou, Hongyan J Ophthalmol Review Article The formation of new blood vessels is an important physiological process that occurs during development. When the body is injured, new blood vessel formation helps the body recuperate by supplying more oxygen and nutrients. However, this mechanism can have a negative effect. In ophthalmologic diseases, such as corneal new blood vessels, neonatal vascular glaucoma, and diabetes retinopathy, the formation of new blood vessels has become a critical component in patient survival. Connexin is a protein that regulates the cellular and molecular material carried by cells. It has been demonstrated that it is widely expressed in vascular endothelial cells, where it forms a slit connection between adjacent cells to promote cell-cell communication via hemichannels, as well as substance exchange into intracellular environments. Numerous studies have demonstrated that connexin in vascular endothelial cells plays an important role in angiogenesis and vascular leakage. The purpose of this study was to investigate the effect between the angiogenesis-associated factor and the connexin. It also reveals the effect of connexin on ophthalmic neovascularization. Hindawi 2022-06-22 /pmc/articles/PMC9242797/ /pubmed/35783340 http://dx.doi.org/10.1155/2022/8105229 Text en Copyright © 2022 Chuyang Xu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Xu, Chuyang
Zhang, Hong
Zhong, Wei
Zhou, Hongyan
The Role of Connexin in Ophthalmic Neovascularization and the Interaction between Connexin and Proangiogenic Factors
title The Role of Connexin in Ophthalmic Neovascularization and the Interaction between Connexin and Proangiogenic Factors
title_full The Role of Connexin in Ophthalmic Neovascularization and the Interaction between Connexin and Proangiogenic Factors
title_fullStr The Role of Connexin in Ophthalmic Neovascularization and the Interaction between Connexin and Proangiogenic Factors
title_full_unstemmed The Role of Connexin in Ophthalmic Neovascularization and the Interaction between Connexin and Proangiogenic Factors
title_short The Role of Connexin in Ophthalmic Neovascularization and the Interaction between Connexin and Proangiogenic Factors
title_sort role of connexin in ophthalmic neovascularization and the interaction between connexin and proangiogenic factors
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242797/
https://www.ncbi.nlm.nih.gov/pubmed/35783340
http://dx.doi.org/10.1155/2022/8105229
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