Four-octyl itaconate improves osteoarthritis by enhancing autophagy in chondrocytes via PI3K/AKT/mTOR signalling pathway inhibition

Osteoarthritis (OA) is a highly prevalent and chronic disorder that is associated with a substantial social and economic burden. Itaconate, as an important regulator of cellular inflammation, is a metabolite synthesised by an enzyme encoded by immune-responsive gene 1. However, there are few studys...

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Detalles Bibliográficos
Autores principales: Pan, Xuekang, Shan, Huajian, Bai, Jinyu, Gao, Tian, Chen, Bao, Shen, Zhonghai, Zhou, Haibin, Lu, Huigen, Sheng, Lei, Zhou, Xiaozhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242998/
https://www.ncbi.nlm.nih.gov/pubmed/35768581
http://dx.doi.org/10.1038/s42003-022-03592-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242998/
https://www.ncbi.nlm.nih.gov/pubmed/35768581
http://dx.doi.org/10.1038/s42003-022-03592-6

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