CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas

Tumor-infiltrating CD8 + T cells progressively lose functionality and fail to reject tumors. The underlying mechanism and re-programing induced by checkpoint blockers are incompletely understood. We show here that genetic ablation or pharmacological inhibition of histone lysine methyltransferase Suv...

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Detalles Bibliográficos
Autores principales: Niborski, Leticia Laura, Gueguen, Paul, Ye, Mengliang, Thiolat, Allan, Ramos, Rodrigo Nalio, Caudana, Pamela, Denizeau, Jordan, Colombeau, Ludovic, Rodriguez, Raphaël, Goudot, Christel, Luccarini, Jean-Michel, Soudé, Anne, Bournique, Bruno, Broqua, Pierre, Pace, Luigia, Baulande, Sylvain, Sedlik, Christine, Quivy, Jean-Pierre, Almouzni, Geneviève, Cohen, José L., Zueva, Elina, Waterfall, Joshua J., Amigorena, Sebastian, Piaggio, Eliane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243005/
https://www.ncbi.nlm.nih.gov/pubmed/35768432
http://dx.doi.org/10.1038/s41467-022-31504-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243005/
https://www.ncbi.nlm.nih.gov/pubmed/35768432
http://dx.doi.org/10.1038/s41467-022-31504-z

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