Genomic, transcriptomic, and metabolomic profiles of hiPSC-derived dopamine neurons from clinically discordant brothers with identical PRKN deletions

We previously reported on two brothers who carry identical compound heterozygous PRKN mutations yet present with significantly different Parkinson’s Disease (PD) clinical phenotypes. Juvenile cases demonstrate that PD is not necessarily an aging-associated disease. Indeed, evidence for a development...

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Detalles Bibliográficos
Autores principales: Cukier, Holly N., Kim, Hyunjin, Griswold, Anthony J., Codreanu, Simona G., Prince, Lisa M., Sherrod, Stacy D., McLean, John A., Dykxhoorn, Derek M., Ess, Kevin C., Hedera, Peter, Bowman, Aaron B., Neely, M. Diana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243035/
https://www.ncbi.nlm.nih.gov/pubmed/35768426
http://dx.doi.org/10.1038/s41531-022-00346-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243035/
https://www.ncbi.nlm.nih.gov/pubmed/35768426
http://dx.doi.org/10.1038/s41531-022-00346-3

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