Cargando…

A chimeric thermostable M2e and H3 stalk-based universal influenza A virus vaccine

We developed a new chimeric M2e and H3 hemagglutinin (HA) stalk protein vaccine (M2e-H3 stalk) by genetic engineering of modified H3 stalk domain conjugated with conserved M2e epitopes to overcome the drawbacks of low efficacy by monomeric domain-based universal vaccines. M2e-H3 stalk protein expres...

Descripción completa

Detalles Bibliográficos
Autores principales:	Subbiah, Jeeva, Oh, Judy, Kim, Ki-Hye, Shin, Chong-Hyun, Park, Bo Ryoung, Bhatnagar, Noopur, Seong, Baik-Lin, Wang, Bao-Zhong, Kang, Sang-Moo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243060/ https://www.ncbi.nlm.nih.gov/pubmed/35768475 http://dx.doi.org/10.1038/s41541-022-00498-6

Ejemplares similares

Thermostable H1 hemagglutinin stem with M2e epitopes provides broad cross-protection against group1 and 2 influenza A viruses
por: Subbbiah, Jeeva, et al.
Publicado: (2022)

Universal protection against influenza viruses by multi-subtype neuraminidase and M2 ectodomain virus-like particle
por: Kim, Ki-Hye, et al.
Publicado: (2022)

Immunogenicity and Neutralizing Activity Comparison of SARS-CoV-2 Spike Full-Length and Subunit Domain Proteins in Young Adult and Old-Aged Mice
por: Kim, Ki-Hye, et al.
Publicado: (2021)

Adjuvant Effects of a New Saponin Analog VSA-1 on Enhancing Homologous and Heterosubtypic Protection by Influenza Virus Vaccination
por: Bhatnagar, Noopur, et al.
Publicado: (2022)

Heterologous Prime-Boost Vaccination with Inactivated Influenza Viruses Induces More Effective Cross-Protection than Homologous Repeat Vaccination
por: Bhatnagar, Noopur, et al.
Publicado: (2023)

Broad cross protection by recombinant live attenuated influenza H3N2 seasonal virus expressing conserved M2 extracellular domain in a chimeric hemagglutinin
por: Park, Bo Ryoung, et al.
Publicado: (2021)

Recombinant Live Attenuated Influenza Virus Expressing Conserved G-Protein Domain in a Chimeric Hemagglutinin Molecule Induces G-Specific Antibodies and Confers Protection against Respiratory Syncytial Virus
por: Jung, Yu-Jin, et al.
Publicado: (2020)

Hemagglutinin virus-like particles incorporated with membrane-bound cytokine adjuvants provide protection against homologous and heterologous influenza virus challenge in aged mice
por: Park, Bo Ryoung, et al.
Publicado: (2023)

An Update on mRNA-Based Viral Vaccines
por: Jeeva, Subbiah, et al.
Publicado: (2021)

Towards Goals to Refine Prophylactic and Therapeutic Strategies Against COVID-19 Linked to Aging and Metabolic Syndrome
por: Shin, Chong-Hyun, et al.
Publicado: (2021)

Rational design of an influenza-COVID-19 chimeric protective vaccine with HA-stalk and S-RBD
por: Li, Yulei, et al.
Publicado: (2023)

CERN stalks mysteries of the universe
por: Parish, C
Publicado: (1988)

A chimeric haemagglutinin-based influenza split virion vaccine adjuvanted with AS03 induces protective stalk-reactive antibodies in mice
por: Nachbagauer, Raffael, et al.
Publicado: (2016)

Generation and Characterization of Universal Live-Attenuated Influenza Vaccine Candidates Containing Multiple M2e Epitopes
por: Kotomina, Tatiana, et al.
Publicado: (2020)

A Strategy to Elicit M2e-Specific Antibodies Using a Recombinant H7N9 Live Attenuated Influenza Vaccine Expressing Multiple M2e Tandem Repeats
por: Mezhenskaya, Daria, et al.
Publicado: (2021)

Delayed Puberty due to Pituitary Stalk Dysgenesis and Ectopic Neurohypophysis
por: Yoo, Hye Jin, et al.
Publicado: (2006)

Transcriptome signatures preceding the induction of anti-stalk antibodies elicited after universal influenza vaccination
por: Aydillo, Teresa, et al.
Publicado: (2022)

The Quest for a Truly Universal Influenza Vaccine
por: Jang, Yo Han, et al.
Publicado: (2019)

Construction of Novel Thermostable Chimeric Vaccine Candidates for Genotype VII Newcastle Disease Virus
por: Cao, Yongzhong, et al.
Publicado: (2022)

Protective Immunity Based on the Conserved Hemagglutinin Stalk Domain and Its Prospects for Universal Influenza Vaccine Development
por: Khanna, Madhu, et al.
Publicado: (2014)

Influenza Anti-Stalk Antibodies: Development of a New Method for the Evaluation of the Immune Responses to Universal Vaccine
por: Manenti, Alessandro, et al.
Publicado: (2020)

Options and Obstacles for Designing a Universal Influenza Vaccine
por: Jang, Yo Han, et al.
Publicado: (2014)

Hemagglutinin Quantitative ELISA-based Potency Assay for Trivalent Seasonal Influenza Vaccine Using Group-Specific Universal Monoclonal Antibodies
por: Chae, Wonil, et al.
Publicado: (2019)

Adaptive mutations of neuraminidase stalk truncation and deglycosylation confer enhanced pathogenicity of influenza A viruses
por: Park, Sehee, et al.
Publicado: (2017)

Immune Responses Elicited by Live Attenuated Influenza Vaccines as Correlates of Universal Protection against Influenza Viruses
por: Jang, Yo Han, et al.
Publicado: (2021)

Chimeric Avidin – NMR Structure and Dynamics of a 56 kDa Homotetrameric Thermostable Protein
por: Tossavainen, Helena, et al.
Publicado: (2014)

Improving Thermostability of Chimeric Enzymes Generated by Domain Shuffling Between Two Different Original Glucoamylases
por: Chen, Zhongxiu, et al.
Publicado: (2022)

Toward a universal influenza vaccine: from the perspective of protective efficacy
por: Jang, Yo Han, et al.
Publicado: (2013)

Influenza Virus-like Particle-Based Hybrid Vaccine Containing RBD Induces Immunity against Influenza and SARS-CoV-2 Viruses
por: Bommireddy, Ramireddy, et al.
Publicado: (2022)

Influenza Virus Vaccine Based on the Conserved Hemagglutinin Stalk Domain
por: Steel, John, et al.
Publicado: (2010)

An Adenovirus-Vectored Influenza Vaccine Induces Durable Cross-Protective Hemagglutinin Stalk Antibody Responses in Mice
por: Kim, Eun Hye, et al.
Publicado: (2017)

Emergence and Genetic Variation of Neuraminidase Stalk Deletions in Avian Influenza Viruses
por: Li, Jinling, et al.
Publicado: (2011)

Adjuvants and Immunization Strategies to Induce Influenza Virus Hemagglutinin Stalk Antibodies
por: Goff, Peter H., et al.
Publicado: (2013)

Stalking influenza by vaccination with pre-fusion headless HA mini-stem
por: Valkenburg, Sophie A., et al.
Publicado: (2016)

The influenza virus hemagglutinin head evolves faster than the stalk domain
por: Kirkpatrick, Ericka, et al.
Publicado: (2018)

Stalking SARS
por: Harding, Anne
Publicado: (2005)

The Impact of Stalking and Its Predictors: Characterizing the Needs of Stalking Victims
por: Storey, Jennifer E., et al.
Publicado: (2023)

Cryo-electron Microscopy Structures of Chimeric Hemagglutinin Displayed on a Universal Influenza Vaccine Candidate
por: Tran, Erin E. H., et al.
Publicado: (2016)

The potential of a universal influenza virus-like particle vaccine expressing a chimeric cytokine
por: Nerome, Kuniaki, et al.
Publicado: (2022)

Bioprocess development for universal influenza vaccines based on inactivated split chimeric and mosaic hemagglutinin viruses
por: Puente-Massaguer, Eduard, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_90huqi3n22mmp9fgcuoakaqbv8