High prevalence of somatic PIK3CA and TP53 pathogenic variants in the normal mammary gland tissue of sporadic breast cancer patients revealed by duplex sequencing

The mammary gland undergoes hormonally stimulated cycles of proliferation, lactation, and involution. We hypothesized that these factors increase the mutational burden in glandular tissue and may explain high cancer incidence rate in the general population, and recurrent disease. Hence, we investiga...

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Detalles Bibliográficos
Autores principales: Kostecka, Anna, Nowikiewicz, Tomasz, Olszewski, Paweł, Koczkowska, Magdalena, Horbacz, Monika, Heinzl, Monika, Andreou, Maria, Salazar, Renato, Mair, Theresa, Madanecki, Piotr, Gucwa, Magdalena, Davies, Hanna, Skokowski, Jarosław, Buckley, Patrick G., Pęksa, Rafał, Śrutek, Ewa, Szylberg, Łukasz, Hartman, Johan, Jankowski, Michał, Zegarski, Wojciech, Tiemann-Boege, Irene, Dumanski, Jan P., Piotrowski, Arkadiusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243094/
https://www.ncbi.nlm.nih.gov/pubmed/35768433
http://dx.doi.org/10.1038/s41523-022-00443-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243094/
https://www.ncbi.nlm.nih.gov/pubmed/35768433
http://dx.doi.org/10.1038/s41523-022-00443-9

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