Cargando…

High prevalence of somatic PIK3CA and TP53 pathogenic variants in the normal mammary gland tissue of sporadic breast cancer patients revealed by duplex sequencing

The mammary gland undergoes hormonally stimulated cycles of proliferation, lactation, and involution. We hypothesized that these factors increase the mutational burden in glandular tissue and may explain high cancer incidence rate in the general population, and recurrent disease. Hence, we investiga...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kostecka, Anna, Nowikiewicz, Tomasz, Olszewski, Paweł, Koczkowska, Magdalena, Horbacz, Monika, Heinzl, Monika, Andreou, Maria, Salazar, Renato, Mair, Theresa, Madanecki, Piotr, Gucwa, Magdalena, Davies, Hanna, Skokowski, Jarosław, Buckley, Patrick G., Pęksa, Rafał, Śrutek, Ewa, Szylberg, Łukasz, Hartman, Johan, Jankowski, Michał, Zegarski, Wojciech, Tiemann-Boege, Irene, Dumanski, Jan P., Piotrowski, Arkadiusz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243094/ https://www.ncbi.nlm.nih.gov/pubmed/35768433 http://dx.doi.org/10.1038/s41523-022-00443-9

Ejemplares similares

Increased yields of duplex sequencing data by a series of quality control tools
por: Povysil, Gundula, et al.
Publicado: (2021)

Increased yields of duplex sequencing data by a series of quality control tools
por: Povysil, Gundula, et al.
Publicado: (2021)

Family reunion via error correction: an efficient analysis of duplex sequencing data
por: Stoler, Nicholas, et al.
Publicado: (2020)

Discovery of an unusually high number of de novo mutations in sperm of older men using duplex sequencing
por: Salazar, Renato, et al.
Publicado: (2022)

Clinical outcomes of an intraoperative surgical margin assessment using the fresh frozen section method in patients with invasive breast cancer undergoing breast-conserving surgery – a single center analysis
por: Nowikiewicz, Tomasz, et al.
Publicado: (2019)

Plasma protein changes reflect colorectal cancer development and associated inflammation
por: Urbiola-Salvador, Víctor, et al.
Publicado: (2023)

Analysis of the causes of false negative and false positive results of preoperative axillary ultrasound in patients with early breast cancer – a single-centre study
por: Nowikiewicz, Tomasz, et al.
Publicado: (2018)

Comprehensive cancer-oriented biobanking resource of human samples for studies of post-zygotic genetic variation involved in cancer predisposition
por: Filipowicz, Natalia, et al.
Publicado: (2022)

Prospective evaluation of muscle strength and spine joint motility of patients who underwent surgery for colorectal cancer by open and laparoscopic methods
por: Głowacka-Mrotek, Iwona, et al.
Publicado: (2019)

Did the COVID-19 Pandemic Truly Adversely Affect Disease Progress and Therapeutic Options in Breast Cancer Patients? A Single-Centre Analysis
por: Nowikiewicz, Tomasz, et al.
Publicado: (2022)

Influence of the COVID-19 pandemic on diagnostic and treatment options for breast cancer patients – assessment from a point of view of a single oncology centre
por: Nowikiewicz, Tomasz, et al.
Publicado: (2023)

Clinical relevance of a degree of extracapsular extension in a sentinel lymph node in breast cancer patients: a single-centre study
por: Nowikiewicz, Tomasz, et al.
Publicado: (2021)

Clinical outcomes of hyperbaric oxygen therapy in treatment of postoperative chronic Pseudomonas aeruginosa wound infection following implant reconstruction of the breast
por: Nowikiewicz, Tomasz, et al.
Publicado: (2019)

Sexual Functioning in Female Patients Undergoing Surgical Treatment for Colorectal Cancer—A Single-Center, Prospective Triple Timepoint Yearly Follow-Up
por: Tarkowska, Magdalena, et al.
Publicado: (2022)

Prospective Evaluation of the Quality of Life of Patients after Surgical Treatment of Rectal Cancer: A 12-Month Cohort Observation
por: Tarkowska, Magdalena, et al.
Publicado: (2022)

The Impact of Surgical Techniques in Patients with Rectal Cancer on Spine Mobility and Abdominal Muscle Strength—A Prospective Study
por: Głowacka-Mrotek, Iwona, et al.
Publicado: (2022)

Diagnostic value of preoperative axillary lymph node ultrasound assessment in patients with breast cancer qualified for sentinel lymph node biopsy
por: Nowikiewicz, Tomasz, et al.
Publicado: (2015)

Quality of Life in Women Subjected to Surgical Treatment of Breast Cancer Depending on the Procedure Performed within the Breast and Axillary Fossa—A Single-Center, One Year Prospective Analysis
por: Tarkowska, Magdalena, et al.
Publicado: (2021)

Evaluation of Late Postural Complications in Breast Cancer Patients Undergoing Breast-Conserving Therapy in Relation to the Type of Axillary Intervention-Cross-Sectional Study
por: Głowacka-Mrotek, Iwona, et al.
Publicado: (2021)

The Prevalence of Back Pain in Patients Operated on Due to Colorectal Cancer Depending on the Type of Surgical Procedure Performed
por: Głowacka-Mrotek, Iwona, et al.
Publicado: (2023)

Size matters: the impact of nucleus size on results from spatial transcriptomics
por: Mohammadi, Elyas, et al.
Publicado: (2023)

Foot posture in female patients 5 years after breast-conserving surgery: a case–control study
por: Głowacka-Mrotek, Iwona, et al.
Publicado: (2018)

Evaluation of changes to foot shape in females 5 years after mastectomy: a case–control study
por: Głowacka-Mrotek, Iwona, et al.
Publicado: (2017)

Evaluation of distant sequelae of breast cancer treatment among patients after breast-conserving surgery depending on the type of intervention in the axillary fossa
por: Głowacka-Mrotek, Iwona, et al.
Publicado: (2018)

Assessment of quality of life in women five years after breast cancer surgery, members of Breast Cancer Self-Help Groups – non-randomized, cross-sectional study
por: Sowa, Magdalena, et al.
Publicado: (2018)

Overall treatment outcome – analysis of long-term results of rectal cancer treatment on the basis of a new parameter
por: Jankowski, Michal, et al.
Publicado: (2020)

Pathogenic postzygotic mosaicism in the tyrosine receptor kinase pathway: potential unidentified human disease hidden away in a few cells
por: Tiemann‐Boege, Irene, et al.
Publicado: (2020)

Post-Zygotic and Inter-Individual Structural Genetic Variation in a Presumptive Enhancer Element of the Locus between the IL10Rβ and IFNAR1 Genes
por: Razzaghian, Hamid Reza, et al.
Publicado: (2013)

Analysis of Undesirable Sequelae of Sentinel Node Surgery in Breast Cancer Patients – a Prospective Cohort Study
por: Kozak, Dominika, et al.
Publicado: (2017)

Overall survival and disease-free survival in breast cancer patients treated at the Oncology Centre in Bydgoszcz – analysis of more than six years of follow-up
por: Nowikiewicz, Tomasz, et al.
Publicado: (2015)

Sexual functioning and self-esteem in women after mastectomy – a single-centre, non-randomised, cross-sectional study
por: Tarkowska, Magdalena, et al.
Publicado: (2020)

Imaging methods for the local lymphatic system of the axilla in early breast cancer in patients qualified for sentinel lymph node biopsy
por: Nowikiewicz, Tomasz, et al.
Publicado: (2016)

Spectrum of NIPBL gene mutations in Polish patients with Cornelia de Lange syndrome
por: Kuzniacka, Alina, et al.
Publicado: (2012)

Erratum to: Spectrum of NIPBL gene mutations in Polish patients with Cornelia de Lange syndrome
por: Kuzniacka, Alina, et al.
Publicado: (2013)

Personalized health risk assessment based on single-cell RNA sequencing analysis of a male with 45, X/48, XYYY karyotype
por: Koczkowska, Magdalena, et al.
Publicado: (2022)

Signatures of post-zygotic structural genetic aberrations in the cells of histologically normal breast tissue that can predispose to sporadic breast cancer
por: Forsberg, Lars A., et al.
Publicado: (2015)

(18)F-FLT PET/CT in Patients with Gastric Carcinoma
por: Małkowski, Bogdan, et al.
Publicado: (2013)

Detection of somatic BRCA1/2 mutations in ovarian cancer – next‐generation sequencing analysis of 100 cases
por: Koczkowska, Magdalena, et al.
Publicado: (2016)

Yamogenin-Induced Cell Cycle Arrest, Oxidative Stress, and Apoptosis in Human Ovarian Cancer Cell Line
por: Stefanowicz-Hajduk, Justyna, et al.
Publicado: (2022)

Detection of BRCA1/2 mutations in circulating tumor DNA from patients with ovarian cancer
por: Ratajska, Magdalena, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ac7njd04f8c02obgsi274e7av0