Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277

The KCNQ1 ion channel plays critical physiological roles in electrical excitability and K(+) recycling in organs including the heart, brain, and gut. Loss of function is relatively common and can cause sudden arrhythmic death, sudden infant death, epilepsy and deafness. Here, we report cryogenic ele...

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Detalles Bibliográficos
Autores principales: Willegems, Katrien, Eldstrom, Jodene, Kyriakis, Efthimios, Ataei, Fariba, Sahakyan, Harutyun, Dou, Ying, Russo, Sophia, Van Petegem, Filip, Fedida, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243137/
https://www.ncbi.nlm.nih.gov/pubmed/35768468
http://dx.doi.org/10.1038/s41467-022-31526-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243137/
https://www.ncbi.nlm.nih.gov/pubmed/35768468
http://dx.doi.org/10.1038/s41467-022-31526-7

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