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Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277
The KCNQ1 ion channel plays critical physiological roles in electrical excitability and K(+) recycling in organs including the heart, brain, and gut. Loss of function is relatively common and can cause sudden arrhythmic death, sudden infant death, epilepsy and deafness. Here, we report cryogenic ele...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243137/ https://www.ncbi.nlm.nih.gov/pubmed/35768468 http://dx.doi.org/10.1038/s41467-022-31526-7 |