Cross-seeding of WT amyloid-β with Arctic but not Italian familial mutants accelerates fibril formation in Alzheimer's disease

Alzheimer’s disease (AD) involves the neurotoxic self-assembly of a 40 and 42 residue peptide, Amyloid-β (Aβ). Inherited early-onset AD can be caused by single point mutations within the Aβ sequence, including Arctic (E22G) and Italian (E22K) familial mutants. These mutations are heterozygous, resul...

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Detalles Bibliográficos
Autores principales: Liang, Ruina, Tian, Yao, Viles, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243174/
https://www.ncbi.nlm.nih.gov/pubmed/35643314
http://dx.doi.org/10.1016/j.jbc.2022.102071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243174/
https://www.ncbi.nlm.nih.gov/pubmed/35643314
http://dx.doi.org/10.1016/j.jbc.2022.102071

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