Discovery of a small-molecule inhibitor of the TRIP8b–HCN interaction with efficacy in neurons

Major depressive disorder is a critical public health problem with a lifetime prevalence of nearly 17% in the United States. One potential therapeutic target is the interaction between hyperpolarization-activated cyclic nucleotide–gated (HCN) channels and an auxiliary subunit of the channel named te...

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Detalles Bibliográficos
Autores principales: Han, Ye, Iyamu, Iredia D., Clutter, Matthew R., Mishra, Rama K., Lyman, Kyle A., Zhou, Chengwen, Michailidis, Ioannis, Xia, Maya Y., Sharma, Horrick, Luan, Chi-Hao, Schiltz, Gary E., Chetkovich, Dane M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243175/
https://www.ncbi.nlm.nih.gov/pubmed/35623388
http://dx.doi.org/10.1016/j.jbc.2022.102069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243175/
https://www.ncbi.nlm.nih.gov/pubmed/35623388
http://dx.doi.org/10.1016/j.jbc.2022.102069

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