Loss of the BRCA1-PALB2 interaction accelerates p53-associated tumor development in mice

The BRCA1-PALB2-BRCA2 axis, or the BRCA pathway, plays key roles in genome stability maintenance and suppression of breast and several other cancers. Due to frequent p53 mutations in human BRCA1 breast cancers and mouse mammary tumors from Brca1, Brca2 and Palb2 conditional knockout models, it is of...

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Detalles Bibliográficos
Autores principales: Mahdi, Amar H., Huo, Yanying, Chen, Ying, Selenica, Pier, Sharma, Anchal, Merritt, Elise, Barnard, Nicola, Chan, Chang, Ganesan, Shridar, Reis-Filho, Jorge S., Weigelt, Britta, De, Subhajyoti, Xia, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2020
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243321/
https://www.ncbi.nlm.nih.gov/pubmed/35782971
http://dx.doi.org/10.1016/j.gendis.2020.08.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243321/
https://www.ncbi.nlm.nih.gov/pubmed/35782971
http://dx.doi.org/10.1016/j.gendis.2020.08.012

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