Santalol Isomers Inhibit Transthyretin Amyloidogenesis and Associated Pathologies in Caenorhabditis elegans

Transthyretin (TTR) is a homotetrameric protein found in human serum and is implicated in fatal inherited amyloidoses. Destabilization of native TTR confirmation resulting from mutation, environmental changes, and aging causes polymerization and amyloid fibril formation. Although several small molec...

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Detalles Bibliográficos
Autores principales: Mohankumar, Amirthalingam, Kalaiselvi, Duraisamy, Thiruppathi, Govindhan, Muthusaravanan, Sivaramakrishnan, Vijayakumar, Subramaniam, Suresh, Rahul, Tawata, Shinkichi, Sundararaj, Palanisamy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243336/
https://www.ncbi.nlm.nih.gov/pubmed/35784752
http://dx.doi.org/10.3389/fphar.2022.924862

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243336/
https://www.ncbi.nlm.nih.gov/pubmed/35784752
http://dx.doi.org/10.3389/fphar.2022.924862

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