Cargando…
The mevalonate pathway promotes the metastasis of osteosarcoma by regulating YAP1 activity via RhoA
Osteosarcoma is the most common malignant bone tumour, and the metastasis of osteosarcoma is an important cause of death. Evidence has shown that the mevalonate pathway is highly activated and is expected to be a new target for tumour therapy. In this study, we investigated the effect of mevalonate...
Autores principales: | Du, Xing, Ou, Yunsheng, Zhang, Muzi, Li, Kai, Huang, Wei, Jiang, Dianming |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Chongqing Medical University
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243346/ https://www.ncbi.nlm.nih.gov/pubmed/35782968 http://dx.doi.org/10.1016/j.gendis.2020.11.009 |
Ejemplares similares
-
SAR1A regulates the RhoA/YAP and autophagy signaling pathways to influence osteosarcoma invasion and metastasis
por: Zhan, Fangbiao, et al.
Publicado: (2022) -
RhoA enhances osteosarcoma resistance to MPPa-PDT via the Hippo/YAP signaling pathway
por: Zhan, Fangbiao, et al.
Publicado: (2021) -
Compromized geranylgeranylation of RhoA and Rac1 in mevalonate kinase deficiency
por: Henneman, L., et al.
Publicado: (2010) -
BMPR2 promotes invasion and metastasis via the RhoA-ROCK-LIMK2 pathway in human osteosarcoma cells
por: Wang, Shidong, et al.
Publicado: (2017) -
Alantolactone inhibits proliferation, metastasis and promotes apoptosis of human osteosarcoma cells by suppressing Wnt/β-catenin and MAPKs signaling pathways
por: Yang, Chunmei, et al.
Publicado: (2020)