Cargando…

Presenilin Deficiency Increases Susceptibility to Oxidative Damage in Fibroblasts

Alzheimer’s disease (AD) is a genetic and sporadic neurodegenerative disease characterized by extracellular amyloid-β-protein (Aβ) aggregates as amyloid plaques and neuronal loss in the brain parenchyma of patients. Familial AD (FAD) is found to be genetically linked to missense mutations either in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zou, Kun, Islam, Sadequl, Sun, Yang, Gao, Yuan, Nakamura, Tomohisa, Komano, Hiroto, Tomita, Taisuke, Michikawa, Makoto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243443/ https://www.ncbi.nlm.nih.gov/pubmed/35783133 http://dx.doi.org/10.3389/fnagi.2022.902525

Ejemplares similares

Presenilin 1 deficiency impairs Aβ42-to-Aβ40- and angiotensin-converting activities of ACE
por: Gao, Yuan, et al.
Publicado: (2023)

New amyloid plaques or a game of hide-and-seek?
por: Zou, Kun, et al.
Publicado: (2008)

High temperature promotes amyloid β-protein production and γ-secretase complex formation via Hsp90
por: Noorani, Arshad Ali, et al.
Publicado: (2021)

Aβ42 treatment of the brain side reduced the level of flotillin from endothelial cells on the blood side via FGF-2 signaling in a blood–brain barrier model
por: Nakamura, Tomohisa, et al.
Publicado: (2023)

Presenilin-dependent intramembrane cleavage of ephrin-B1
por: Tomita, Taisuke, et al.
Publicado: (2006)

Angiotensin type 1a receptor deficiency decreases amyloid β-protein generation and ameliorates brain amyloid pathology
por: Liu, Junjun, et al.
Publicado: (2015)

Flexible and Accurate Substrate Processing with Distinct Presenilin/γ-Secretases in Human Cortical Neurons
por: Watanabe, Hirotaka, et al.
Publicado: (2021)

Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency
por: Reddy, Kavya, et al.
Publicado: (2016)

The presenilins
por: Tandon, Anurag, et al.
Publicado: (2002)

Identification of Ubiquilin, a Novel Presenilin Interactor That Increases Presenilin Protein Accumulation
por: Mah, Alex L., et al.
Publicado: (2000)

Cholesterol Regulates Exosome Release in Cultured Astrocytes
por: Abdullah, Mohammad, et al.
Publicado: (2021)

Presenilin-Deficient Neurons and Astrocytes Display Normal Mitochondrial Phenotypes
por: Contino, Sabrina, et al.
Publicado: (2021)

Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generation
por: Ohki, Yu, et al.
Publicado: (2014)

Adult hippocampal neurogenesis occurs in the absence of Presenilin 1 and Presenilin 2
por: Dhaliwal, Jagroop, et al.
Publicado: (2018)

Structure and dynamics of γ-secretase with presenilin 2 compared to presenilin 1
por: Dehury, Budheswar, et al.
Publicado: (2019)

Presenilin 2-Dependent Maintenance of Mitochondrial Oxidative Capacity and Morphology
por: Contino, Sabrina, et al.
Publicado: (2017)

Role of Presenilin in Mitochondrial Oxidative Stress and Neurodegeneration in Caenorhabditis elegans
por: Sarasija, Shaarika, et al.
Publicado: (2018)

Specificity of presenilin‐1‐ and presenilin‐2‐dependent γ‐secretases towards substrate processing
por: Stanga, Serena, et al.
Publicado: (2017)

Pathological and physiological functions of presenilins
por: Vetrivel, Kulandaivelu S, et al.
Publicado: (2006)

Presenilin/γ-Secretase and Inflammation
por: Saura, Carlos A.
Publicado: (2010)

Increased Susceptibility to Glaucomatous Damage in Microfibril Deficient Mice
por: Wu, Hang-Jing, et al.
Publicado: (2020)

Parkin acts as a transcription factor modulating presenilin-1 and presenilin-2 promoter transactivations
por: Duplan, Eric, et al.
Publicado: (2013)

CSF Presenilin-1 complexes are increased in Alzheimer’s disease
por: García-Ayllón, María-Salud, et al.
Publicado: (2013)

Inhibition of γ-Secretase Leads to an Increase in Presenilin-1
por: Sogorb-Esteve, Aitana, et al.
Publicado: (2017)

Histone Deacetylase Inhibitor Alleviates the Neurodegenerative Phenotypes and Histone Dysregulation in Presenilins-Deficient Mice
por: Cao, Ting, et al.
Publicado: (2018)

Mitophagy Failure in Fibroblasts and iPSC-Derived Neurons of Alzheimer’s Disease-Associated Presenilin 1 Mutation
por: Martín-Maestro, Patricia, et al.
Publicado: (2017)

Modeling Presenilin-Dependent Familial Alzheimer's Disease: Emphasis on Presenilin Substrate-Mediated Signaling and Synaptic Function
por: Parent, Angèle T., et al.
Publicado: (2010)

Ibuprofen Rescues Abnormalities in Periodontal Tissues in Conditional Presenilin 1 and Presenilin 2 Double Knockout Mice
por: Su, Jiansheng, et al.
Publicado: (2013)

Data on solubilization, identification, and thermal stability of human Presenilin-2
por: Yang, Ge, et al.
Publicado: (2018)

Influence of solubilization and AD-mutations on stability and structure of human presenilins
por: Yang, Ge, et al.
Publicado: (2017)

Presenilins are Essential for Regulating Neurotransmitter Release
por: Zhang, Chen, et al.
Publicado: (2009)

Presenilins in Alzheimer’s disease and frontotemporal dementia
por: Shen, Jie
Publicado: (2012)

Presenilin Promotes Dietary Copper Uptake
por: Southon, Adam, et al.
Publicado: (2013)

Function and dysfunction of presenilin in Alzheimer’s disease
por: Shen, Jie
Publicado: (2013)

Structural biology of presenilin 1 complexes
por: Li, Yi, et al.
Publicado: (2014)

Presenilins and γ-Secretase in Membrane Proteostasis
por: Oikawa, Naoto, et al.
Publicado: (2019)

Accumulation of Phosphorylated β-Catenin Enhances ROS-Induced Cell Death in Presenilin-Deficient Cells
por: Boo, Jung H., et al.
Publicado: (2009)

Current Biomarkers for Alzheimer’s Disease: From CSF to Blood
por: Zou, Kun, et al.
Publicado: (2020)

ATP increases the migration of microglia across the brain endothelial cell monolayer
por: Maeda, Tomoji, et al.
Publicado: (2016)

Presenilin 1 increases association with synaptotagmin 1 during normal aging
por: Keller, Laura J., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_epfdla6ptkehk1p6jj46kk5oje