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Effects of Sarcolemmal Background Ca(2+) Entry and Sarcoplasmic Ca(2+) Leak Currents on Electrophysiology and Ca(2+) Transients in Human Ventricular Cardiomyocytes: A Computational Comparison

The intricate regulation of the compartmental Ca(2+) concentrations in cardiomyocytes is critical for electrophysiology, excitation-contraction coupling, and other signaling pathways. Research into the complex signaling pathways is motivated by cardiac pathologies including arrhythmia and maladaptiv...

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Detalles Bibliográficos
Autores principales: Streiff, Molly E., Sachse, Frank B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243544/
https://www.ncbi.nlm.nih.gov/pubmed/35784869
http://dx.doi.org/10.3389/fphys.2022.916278