Identification of Linomide Derivatives as Potential Anticancer Therapeutics using Molecular Docking Studies

12 analogs bearing a structural similarity to Linomide, a bonafide anticancer agent were synthesized wherein cyclization of substituted dianilides rendered 4-hydroxyquinolin-2(1H)-ones that were subjected to a Mannich reaction to yield 4-hydroxy-3-(substituted-1-ylmethyl) quinolin-2(1H)-one analogs....

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Detalles Bibliográficos
Autores principales: Borges e Soares, Giselle A., Bhattacharya, Tanima, Mamledesai, Shivalingrao, Ai, Zhaoquan, Hasan, Alexandru Madalin, Cavalu, Simona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243562/
https://www.ncbi.nlm.nih.gov/pubmed/35784702
http://dx.doi.org/10.3389/fphar.2022.892914

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243562/
https://www.ncbi.nlm.nih.gov/pubmed/35784702
http://dx.doi.org/10.3389/fphar.2022.892914

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