In vivo efficacy of WCK 6777 (ertapenem/zidebactam) against carbapenemase-producing Klebsiella pneumoniae in the neutropenic murine pneumonia model

OBJECTIVES: Ertapenem has proven to be an effective antimicrobial; however, increasing enzyme-mediated resistance has been noted. Combination with zidebactam, a β-lactam enhancer, is restorative. Human-simulated regimens (HSRs) of ertapenem and zidebactam alone and in combination (WCK 6777; 2 g/2 g...

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Detalles Bibliográficos
Autores principales: Gethers, Matthew, Chen, Iris, Abdelraouf, Kamilia, Nicolau, David P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9244213/
https://www.ncbi.nlm.nih.gov/pubmed/35411395
http://dx.doi.org/10.1093/jac/dkac110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9244213/
https://www.ncbi.nlm.nih.gov/pubmed/35411395
http://dx.doi.org/10.1093/jac/dkac110

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