Optimal target saturation of ligand-blocking anti-GITR antibody IBI37G5 dictates FcγR-independent GITR agonism and antitumor activity

Glucocorticoid-induced tumor necrosis factor receptor (GITR) is a co-stimulatory receptor and an important target for cancer immunotherapy. We herein present a potent FcγR-independent GITR agonist IBI37G5 that can effectively activate effector T cells and synergize with anti-programmed death 1 (PD1)...

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Detalles Bibliográficos
Autores principales: Liu, Huisi, Wu, Weiwei, Sun, Gangyu, Chia, Tiongsun, Cao, Lei, Liu, Xiaodan, Guan, Jian, Fu, Fenggen, Yao, Ying, Wu, Zhihai, Zhou, Shuaixiang, Wang, Jie, Lu, Jia, Kuang, Zhihui, Wu, Min, He, Luan, Shao, Zhiyuan, Wu, Dongdong, Chen, Bingliang, Xu, Wenqing, Wang, Zhizhi, He, Kaijie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245059/
https://www.ncbi.nlm.nih.gov/pubmed/35732156
http://dx.doi.org/10.1016/j.xcrm.2022.100660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245059/
https://www.ncbi.nlm.nih.gov/pubmed/35732156
http://dx.doi.org/10.1016/j.xcrm.2022.100660

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