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Genome-wide expression and methylation analyses reveal aberrant cell adhesion signaling in tyrosine kinase inhibitor-resistant CML cells

Although chronic myeloid leukemia (CML) can be effectively treated using BCR-ABL1 kinase inhibitors, resistance due to kinase alterations or to BCR-ABL1 independent mechanisms remain a therapeutic challenge. For the latter, the underlying mechanisms are widely discussed; for instance, gene expressio...

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Detalles Bibliográficos
Autores principales: Kaehler, Meike, Litterst, Merit, Kolarova, Julia, Böhm, Ruwen, Bruckmueller, Henrike, Ammerpohl, Ole, Cascorbi, Ingolf, Nagel, Inga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245083/
https://www.ncbi.nlm.nih.gov/pubmed/35730629
http://dx.doi.org/10.3892/or.2022.8355