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3,3′-Diindolylmethane improves antitumor immune responses of PD-1 blockade via inhibiting myeloid-derived suppressor cells

BACKGROUND: Immune checkpoint inhibitors that target programmed cell death protein 1 (PD-1) have obtained encouraging results, but a fraction of tumor patients failed to respond to anti-PD-1 treatment due to the existence of multiple immune suppressive elements such as myeloid-derived suppressor cel...

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Detalles Bibliográficos
Autores principales: Sun, Qi, Xiao, Lin, Cui, Zhiying, Yang, Yaping, Ma, Junting, Huang, Zhen, Zhang, Junfeng, Chen, Jiangning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245307/
https://www.ncbi.nlm.nih.gov/pubmed/35773674
http://dx.doi.org/10.1186/s13020-022-00638-z