Tissue-Specific Downregulation of Fatty Acid Synthase Suppresses Intestinal Adenoma Formation via Coordinated Reprograming of Transcriptome and Metabolism in the Mouse Model of Apc-Driven Colorectal Cancer

Altered lipid metabolism is a potential target for therapeutic intervention in cancer. Overexpression of Fatty Acid Synthase (FASN) correlates with poor prognosis in colorectal cancer (CRC). While multiple studies show that upregulation of lipogenesis is critically important for CRC progression, the...

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Detalles Bibliográficos
Autores principales: Drury, James, Young, Lyndsay E. A., Scott, Timothy L., Kelson, Courtney O., He, Daheng, Liu, Jinpeng, Wu, Yuanyan, Wang, Chi, Weiss, Heidi L., Fan, Teresa, Gentry, Matthew S., Sun, Ramon, Zaytseva, Yekaterina Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245602/
https://www.ncbi.nlm.nih.gov/pubmed/35742953
http://dx.doi.org/10.3390/ijms23126510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245602/
https://www.ncbi.nlm.nih.gov/pubmed/35742953
http://dx.doi.org/10.3390/ijms23126510

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